CAS 66148-15-0: 3-Pyridine-2,4,5,6-d4-carboxylic acid

Nicotinic acid-(ring-d4) is an acidic, spectroscopically pure form of nicotinic acid. It has been used in plant resistance studies and for the orientation of hornworms on plants. Nicotinic acid-(ring-d4) also has surface protein binding properties and is a chromatographic technique that can be used to measure the concentration of acetonitrile. This compound is used to calibrate mass spectrometers and has been shown to have anti-inflammatory effects in clinical studies. Nicotinic acid-(ring-d4) is a tryptic digestable, isotopically pure form of nicotinic acid, which can be administered orally as a monotherapy or in combination with other drugs.

Applications Labelled Nicotinic acid. It is a precursor of the coenzymes NAD and NADP. Widely distributed in nature; appreciable amounts are found in liver , fish, yeast and cereal grains. Dietary deficiency is associated with pellagra. The term “niacin” has also been applied to nicotinamide or to other derivatives exhibiting the biological activity of nicotinic acid. Vitamin (enzyme cofactor). References Darby, W.J., et al.: Nutr. Rev., 33, 289 (1975), Black, A., et al.: Eur. J. Clin. Nutr., 54, 395 (2000), Cole, T., et al.: Br. Med. J., 320, 1240 (2000), Forshee, R., et al.: J. Nutr., 134, 2733 (2004),

Vitamin B3-d4

Vitamin B3-d4 (Nicotinic acid-(ring-d4)) is a deuterated substitute for Niacin and can be used to track Niacin metabolism in vivo.