CAS 664985-43-7: 4-chloro-N-(2-dimethylaminoethyl)-2,1,3-benzoxadiazole-7-sulfonamide

DAABD-Cl is a fluorescent derivative of the compound 4-[2-(dimethylamino)ethylaminosulfonyl]-7-chloro-2,1,3-benzoxadiazole. It can be used as an analytical reagent for proteome analysis by liquid chromatography coupled with fluorescence detection and mass spectrometry. DAABD-Cl reacts with proteins in a manner that is specific to the protein sequence it binds to. This reaction leads to a paradigm shift in proteomics research because it can identify proteins without the need for prior knowledge of their sequences. The reaction product is also soluble in water, which eliminates the need for solvents or organic solvents that eliminate other compounds from the sample. DAABD-Cl has been shown to be reactive against aristolochic acid, which could be used as a biomarker for exposure to this toxin.