CAS 67-20-9: Furantoin

Applications A nitrofuran antibiotic with low resistance potential that is rapidly metabolized by mammals. Active against both Gram-positive and Gram-negative bacteria. Nitrofurantoin is also a prooxidant that is cytotoxic due to the generation of intracellular H2O2. Antibacterial.Environmental contaminants; Food contaminants; Heat processing contaminants References Cadwallader, D.E., et al.: Anal. Profiles Drug Subs., 5, 345 (1976), Rogers, R.G., et al.: Am. J. Obstr. Gynecol., 191, 182 (2004),

Nitrofurantoin is an antibiotic that binds to the bacterial ribosome and inhibits protein synthesis. It is used to treat a wide range of infections, including urinary tract infections and its common causes such as E. coli, Citrobacter and Enterococcus. Nitrofurantoin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Nitrofurantoin

Nitrofurantoin is an antimicrobial agent, which is a synthetic chemical compound with bactericidal activity. Its source is synthetic, originating from the nitrofuran class of compounds. Nitrofurantoin's mode of action involves the inhibition of essential bacterial enzymes. It is reduced by bacterial flavoproteins to active intermediates, which subsequently alter or disrupt ribosomal proteins, DNA, and other vital macromolecules within bacterial cells, thereby inhibiting key metabolic processes. Nitrofurantoin is most commonly used in the treatment and prophylaxis of uncomplicated urinary tract infections (UTIs). Its effectiveness is primarily restricted to the urinary tract because it achieves therapeutic concentrations only in urine. It is particularly active against Escherichia coli and some strains of Enterococcus, Klebsiella, and Staphylococcus. Due to its targeted spectrum and localized action, it is generally reserved for infections caused by susceptible organisms within the urinary tract, reducing the risk of systemic side effects. Nitrofurantoin's limited systemic absorption and rapid renal clearance contribute to its targeted action profile, making it a vital option in the specific context of urinary tract infections.

Nitrofurantoin

Nitrofurantoin, an antibiotic, targets bacteria for urinary infections by blocking DNA, RNA, and protein synthesis.

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi