CAS: 677007-74-8

Avatrombopag (AKR-501/E5501) is an oral TPO receptor agonist for thrombocytopenia treatment, approved in 2018.

Avatrombopag maleate is a small molecule that activates platelets by binding to the beta-granule protein receptor. This drug has been shown to improve blood clotting and lower the need for blood transfusions in patients with thrombocytopenia, which is a condition where there are fewer than normal numbers of platelets in the blood. Avatrombopag maleate has also been shown to reduce brain infarct volume after stroke, suggesting that it may be useful for treating ischemic stroke.