CAS: 6792-09-2

Mesaconine is an ingredient from Aconitum carmichaelii Debx..

Stability Moisture Sensitive Applications Mesaconine is an Aconine (A190245) derivative, which is an Aconitine (A189875), a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Derbre, S., et al.: Anal. Bioanal. Chem., 398, 1747 (2010), Li, M., et al.: J. Pharm. Biomed. Anal., 53, 1063 (2010),

Mesaconine is an alkaloid found in the roots of Aconitum species. It has been shown to have a cardiac effect and can be used as an analytical method for detecting other aconitine-type alkaloids in plant or animal samples. Mesaconine is also used to treat metabolic disorders and has been shown to be effective against human serum. The LC-MS/MS method was used as a detection technique for mesaconine, which was found to be sensitive enough to detect concentrations as low as 0.1 μg/mL. The matrix effect may affect the sensitivity of this technique, so it should be carried out in a nutrient solution with a hydroxyl group such as methanol or ethanol. >>END