CAS 68-19-9: Vitamin B12

Cyanocobalamin for peak identification CRS

CYANOCOBALAMIN CRS

Cyanocobalamin for impurity C identification CRS

Vitamin B12 is a water-soluble vitamin that is found in animal products. It is required for the production of red blood cells and DNA, as well as for the maintenance of a healthy nervous system. Vitamin B12 deficiency can lead to a number of health problems, including anemia, nerve damage, and bowel disease. A diagnosis of vitamin B12 deficiency typically involves measuring serum vitamin B12 levels. If the level is low or deficient, other tests may be performed to determine whether there are any underlying causes for this deficiency. Deficiencies in vitamin B12 can be caused by pernicious anemia, dietary restrictions (veganism), or certain medications. A low-dose group study was conducted to evaluate the efficacy of high dose oral cobalamin on reducing homocysteine levels in patients with bowel disease. The experimental model consisted of 34 patients with bowel disease who were randomly assigned to either receive 500 μg oral cobalamin daily or placebo for 3 months. Results show

Vitamin b12 (cyanocobalamin and related compounds with vitamin b12 activity) and its derivatives

Cyanocobalamin, a B-complex vitamin from gut microbes, is essential for blood, DNA, and metabolism; its lack causes anemia and nerve damage.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Vitamin B12 is used as a nutritional supplement and stabilizer in foods. It is also used as a medicine and animal feed supplement. It plays an important role in the synthesis of myelin. It is also used as an antipernicious anemia factor. Further, it is used to treat cyanide poisoning and hereditary deficiency of transcobalamin II. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Stability Hygroscopic Applications Prototype of the family of naturally occurring cobalt coordination compounds knows as corrinoids. Analogs of vitamin B12 which differ only in the β-ligand of the cobalt are termed cobalamins. Synthesized almost exclusively by bacteria. Dietary sources include fish, meat, liver, and dairy products; plants have little or no cobalamins. Converted by the body into its bioactive forms, methylcobalamin and cobamamide, which serve as enzyme cofactors. Severe deficiency may result in megaloblastic anemia and/or neurological impairment. References Rickes, et al.: Science, 107, 396 (1948); Kirschbaum, J., et al.: Anal. Profiles Drug Subs., 10, 183 (1981); Grasbeck, R., et al.: Clin. Biochem., 17, 99 (1984)

Vitamin B12 is a water-soluble vitamin that is essential for the normal production of red blood cells, DNA, and protein. It is also necessary for the maintenance of nerve tissue and the regulation of brain function. This product has been shown to be effective in the prevention and treatment of bowel disease (e.g., Crohn's disease). Vitamin B12 deficiency can lead to anemia, depression, confusion, or nerve damage. The recommended dose for adults is 1 mg per day.