CAS: 680622-70-2

API-1 is a Pin1 inhibitor (IC50: 72.3 nM), enhancing anticancer miRNA biogenesis and inhibiting hepatocellular carcinoma.

O6-[4-(Trifluoroacetamidomethyl)benzyl]guanine is a modified nucleoside that is an inhibitor of microRNAs (miRNAs). It can be used as a therapeutic agent for the treatment of cancer. O6-[4-(Trifluoroacetamidomethyl)benzyl]guanine is orally bioavailable and has shown tumor inhibition in invertebrate models. It is stable in vivo and has been shown to inhibit the activity of miRNA-1, miRNA-2, and miRNA-29b. This molecule also provides optimal orientation for highlighting through its large size, which makes it suitable for use with electron microscopy.

PIN1 inhibitor API-1

Applications O6-[4-(Trifluoroacetamidomethyl)benzyl]guanine (cas# 680622-70-2) is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor. References Pu, W., et al.: Hepatology, 68, 547 (2018)