CAS 683-85-2: dimethylphosphoramidous dichloride

Dimethylphosphoramidous dichloride (N,N-dimethylamidodichlorophosphite) may be used in the synthesis of the following N,N-dimethylamidotetrachlorophosphorane, O-propylchloroformimino-N,N-dimethylamidochlorophosphate, bisarylsulphonyldiazadiphosphetidines. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Dichloro(dimethylamino)phosphine (DCPP) is a nitrogen mustard that can be used as an anti-cancer agent. DCPP binds to the DNA of tumor cells and interferes with the production of DNA by inhibiting the action of DNA polymerase, which is an enzyme that is required for cell replication. DCPP also reacts with the amino group in proteins and nitro groups in lipids, causing cross-linking between molecules. DCPP has been used as a chemical intermediate in Friedel-Crafts reactions, as well as being a precursor to other compounds such as chlorodiphenylphosphine oxide.