2'-Deoxy-2'-fluoroadenosine 5'-(trihydrogen diphosphate), commonly referred to as dFdATP, is a modified nucleotide analog of adenosine triphosphate (ATP). It features a fluorine atom at the 2' position of the ribose sugar, which alters its biochemical properties. This compound is characterized by its ability to inhibit DNA synthesis, making it a valuable tool in molecular biology and cancer research. The presence of the diphosphate group allows it to participate in enzymatic reactions similar to ATP, but the fluorine substitution can hinder its recognition by certain enzymes, thereby affecting its incorporation into DNA. dFdATP is often studied for its potential therapeutic applications, particularly in the context of antiviral and anticancer treatments, as it can interfere with the replication of nucleic acids. Its CAS number, 68357-16-4, is a unique identifier that facilitates its identification in chemical databases. Overall, dFdATP serves as an important compound in understanding nucleotide metabolism and the development of targeted therapies.

2'-deoxy-2'-fluoroadenosine 5'-(trihydrogen diphosphate)

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2'-Deoxy-2'-fluoroadenosine-5'-diphosphate (FAD) is an irreversible enzyme inhibitor that binds to the active site of the decarboxylase enzyme. FAD binds to cytochrome P450 and inhibits aromatase, which is an enzyme responsible for the conversion of testosterone to estradiol. It has been shown that FAD inactivates the enzyme by protonation at the active site. The protonated form of FAD is a nucleophile and forms a covalent bond with the substrate, thereby inhibiting decarboxylases. This inhibition can be reversed by fluoride ions, which are also used as catalysts in organic synthesis reactions involving carboxylic acid derivatives.

CAS 68357-16-4: 2'-deoxy-2'-fluoroadenosine 5'-(trihydrogen diphosphate)

2'-Deoxy-2'-fluoroadenosine-5'-diphosphate

Ref: 3D-ND86951