(S)-4′-Hydroxywarfarin is a chemical compound that belongs to the class of anticoagulants, specifically a derivative of warfarin. It is characterized by its hydroxyl group at the 4' position of the phenyl ring, which contributes to its biological activity. This compound is known for its role in inhibiting vitamin K epoxide reductase, an enzyme critical for the synthesis of clotting factors in the liver, thereby exerting its anticoagulant effects. The stereochemistry of (S)-4′-Hydroxywarfarin indicates that it has a specific spatial arrangement of atoms, which is essential for its interaction with biological targets. In terms of physical properties, it is typically a solid at room temperature and may exhibit solubility in organic solvents. The compound is utilized in pharmacological research and has implications in the study of blood coagulation disorders. Safety and handling precautions are necessary due to its biological activity, and it is important to consider its potential interactions with other medications when used therapeutically.

(S)-4′-Hydroxywarfarin

68407-05-6: 2H-1-Benzopyran-2-one, 4-hydroxy-3-[1-(4-hydroxyphenyl)-3-oxobutyl]-, (S)-, 4-Hydroxy-3-[(1S)-1-(4-hydroxyphenyl)-3-oxobutyl]-2H-1-benzopyran-2-one, (S)-4′-Hydroxywarfarin, 4′-Hydroxy-S-warfarin, 2H-1-Benzopyran-2-one, 4-hydroxy-3-[(1S)-1-(4-hydroxyphenyl)-3-oxobutyl]-

Applications (S)-4’-Hydroxywarfarin is the S-enantiomer of the 4’-hydroxyl metabolite of Warfarin (W498500). Formation of (S)-4’-Hydroxywarfarin is increased by quinidine during Warfarin metabolism.
References Wong, Y.W.J. et al.: Pharm. Res., 6, 982 (1989); Ngui, J. et al.: Drug Metab. Dispos., 29, 877 (2001);


CAS 68407-05-6: (S)-4′-Hydroxywarfarin

(S)-4’-Hydroxy Warfarin

Ref: TR-H996106