CAS 68745-38-0: 5,7-dihydroxy-2-phenyl-2,3-dihydro-4H-chromen-4-one

Pinocembrin is a flavonoid compound, which is a type of polyphenolic molecule, extracted primarily from honey, propolis, and various plants. It is characterized by its unique structure allowing it to function effectively as an antioxidant. The mode of action of Pinocembrin involves scavenging free radicals and reducing oxidative stress, which contributes to its protective effects on cells and tissues. In addition to its antioxidant capabilities, Pinocembrin has been studied for its anti-inflammatory and neuroprotective properties, making it of interest in neurological research. It is under investigation for potential therapeutic applications in treating neurodegenerative diseases, ischemic injury, and other conditions where oxidative damage is a concern. By modulating signaling pathways and inhibiting enzymes involved in inflammatory responses, Pinocembrin helps in maintaining cellular homeostasis. The growing body of evidence supporting its efficacy suggests promising applications in pharmacology, particularly in the development of treatments aimed at protecting neural health and enhancing recovery from brain injuries.

(+/-)-Pinocembrin

Applications Pinocembrin is a flavanoid with antioxidant activity found in damiana, honey, and propolis. Recent studies show that Pinocembrin maybe be a therapeutic option in reducing cerebral ischemia/reperfusion injury as a result of its anti-oxidative and anti-apoptotic effects. Pinocembrin displayed neuroprotective effects in glutamate injury model partly by inhibiting p53 expression causing a lower Bax-Bcl-2 ratio and by inhibiting the release of cytochrome c. References Zhao, J. et al.: J. Ethnopharmacol., 120, 387 (2008); Liu, R. et al.: Brain Res., 1216, 104 (2008); Gao, M. et al.: Eur. J. Pharmacol., 591, 73 (2008);

(+/-)-Pinocembrin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Oxygen-heterocyclic compound

(+/-)-Pinocembrin (NSC-43318), a natural product from axillary pines, is a GPR120 ligand that promotes wound healing in the HaCaT cell line.