CAS 693-25-4: Pentylmagnesium bromide

n-Pentylmagnesium bromide 1M solution in THF

n-Pentyl-magnesium bromide is a compound that is used in the synthesis of pharmaceuticals. It has been shown to have potent anti-inflammatory effects in mouse models of inflammatory bowel disease. The asymmetric synthesis of n-pentyl-magnesium bromide was achieved by reacting magnesium with pentane and hydrochloric acid, which yielded a mixture of diastereoisomers with different boiling points. This mixture was then separated by fractional distillation and purified with silica gel column chromatography. The resulting product was then reacted with sodium carbonate to form the corresponding organometallic salt, which could be used as a catalyst for organic reactions. n-Pentyl-magnesium bromide is also an ns3 protease inhibitor, which may be useful in treating fatty acid metabolism disorders such as diabetes or obesity. Analytical methods such as fluorescence spectroscopy can be used to determine the purity of this product.

n-Pentylmagnesium bromide 2M solution in DEE

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.