CAS 70-53-1: Lysine, hydrochloride (1:1)

DL-Lysine Monohydrochloride

DL-Lysine hydrochloride is a salt of lysine and hydrochloric acid. It is used in clinical settings to treat herpes simplex virus infections and may also be used for treatment of other viral diseases such as cytomegalovirus, varicella zoster virus, or human immunodeficiency virus. The drug is administered intravenously and can be combined with other drugs such as acyclovir or ganciclovir. DL-Lysine hydrochloride has been shown to inhibit the replication of herpes simplex virus (HSV) in tissue culture by interfering with the release of cytoplasm from the infected cell. In cell culture studies, DL-lysine hydrochloride has been shown to inhibit HSV's ability to bind to cells' surfaces and enter cells.

DL-Lysine monohydrochloride acts as an intermediate in the preparation of 3-amino-azepan-2-one. It also serves as an essential amino acid. It is used as animal feed. In addition to this, it is used in the construction of polylysine polymers, which finds application in lysine-based polypeptide gels and films. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

The solubility of DL-Lysine hydrochloride in water is low, with a solubility of 0.01 g/100 mL at 25 °C. The pH of the solution is 7.0 and the concentration is 10.00%. The pH of the solution was determined using a pH meter. The concentration was determined by weight measurements using a balance and a volumetric flask. DL-Lysine hydrochloride reacts with hydrochloric acid to form an amide linkage between lysine residues on adjacent polypeptides or proteins, which may be used as a cross-linking agent for cell culture experiments. This compound has been shown to inhibit the growth of herpes simplex virus type 1 (HSV-1) in cell culture experiments, although it has no effect on HSV-2 because it lacks an amino group at position 2 on its side chain.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.