CAS 7014-39-3: Neoisoliquiritin

Neoisoliquiritin is a bioactive flavonoid glycoside, which is a derivative of isoliquiritin. It is primarily sourced from the roots of Glycyrrhiza species, commonly known as licorice plants. This compound is formed through the natural modifications of flavonoids within the plant, involving glycosylation processes that enhance its solubility and stability. The mode of action of Neoisoliquiritin involves antioxidant properties, where it effectively scavenges free radicals and inhibits oxidative stress pathways. This action is primarily attributed to its ability to donate hydrogen atoms or electrons, neutralizing reactive oxygen species (ROS) and thereby preventing cellular damage. Neoisoliquiritin has been explored for its potential applications in various biomedical fields, including pharmacology and nutraceuticals. Its potent antioxidant properties make it a candidate for research in chronic disease prevention, particularly in conditions associated with oxidative stress such as cardiovascular diseases, inflammatory disorders, and certain types of cancer. Moreover, its role in modulating cellular signaling pathways opens avenues for investigating its therapeutic potential as a protective agent against cellular and molecular damage.

Isoliquiritin from Spatholobus suberectus halts breast cancer growth by targeting GRP78 and β-catenin.