CAS 7019-01-4: Benzenamine, 4-(phenylsulfonyl)-

Applications 4-Phenylsulfonylaniline is used in the preparation of novel Flufenamic acid analogues as inhibitors of androgen receptor mediated transcription. References Kemppainen, J., et al.: J. Biol. Chem., 267, 968 (1992), Amler, L., et al.: Cancer Res., 60, 6134 (2000), Klotz, L., et al.: Clin. Prostate Cancer, 3, 215 (2005),

Other aromatic organo-sulfur compounds (excluding pesticides)

4-Phenylsulfonylaniline is an antibacterial agent that belongs to the group of sulfide, sulfoxide, and tuberculostatic agents. It has been shown to be effective against bacteria in environmental samples. 4-Phenylsulfonylaniline has anti-tuberculostatic activity, which may be due to its ability to form a covalent bond with DNA. This binding prevents transcription and replication of bacterial DNA and causes DNA strand breakage. 4-Phenylsulfonylaniline is also known as a drug development candidate for tuberculosis treatment because it has been shown to be resistant to some strains of Mycobacterium tuberculosis.