CAS 70241-09-7: Physalin H

Physalin H inhibits Hh signal/GLI1-DNA, induces quinone reductase (IR 3.74), suppresses T cells, and is cytotoxic to cancer cells and Leishmania major.

Physalin H is a steroidal lactone compound, which is a naturally occurring product isolated from plants of the Physalis genus. This compound is primarily extracted from the calyces or leaves of these plants, known for their traditional medicinal uses. Physalin H exhibits its mode of action through the modulation of various biochemical pathways, such as the inhibition of the NF-kB signaling pathway, which leads to its notable anti-inflammatory and anti-cancer effects. In scientific investigations, Physalin H has demonstrated potential applications in oncology and inflammatory disease treatment. It exhibits cytotoxic effects against various cancer cell lines, offering promise as a lead compound for anti-cancer drug development. Additionally, its ability to suppress inflammatory responses makes it a candidate for research into treatments for diseases characterized by excessive inflammation. Further studies on its pharmacokinetics, bioavailability, and mechanism of action are required to fully elucidate its therapeutic potential and applicability in medicinal chemistry.