CAS 70459-04-0: N-Formylnorfloxacin

1-Ethyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid is an advanced fluoroquinolone antibiotic, which is synthetically derived. This compound operates by efficiently inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes which are critical for bacterial DNA replication, transcription, and repair. The inhibition of these enzymes interferes with the DNA processes, ultimately leading to bacterial cell death. The compound is primarily utilized in combating a broad spectrum of bacterial infections, particularly those caused by Gram-negative and certain Gram-positive bacteria. Its mechanism of action makes it invaluable in clinical settings where multi-drug resistant bacteria are prevalent. Research applications include studying bacterial resistance mechanisms and developing novel antibacterial agents. As a fluoroquinolone, its efficacy, spectrum of activity, and pharmacokinetic properties are extensively studied to optimize therapeutic outcomes and minimize resistance development.