CAS: 70993-70-3

Applications Cefmetazole Lactone is an impurity of cefmetazole (C242850), which is a semi-synthetic antibiotic derived from Cephamycin. Antibacterial. References Nakao, H., et al.: J. Antibiot., 29, 554 (1976), Iwata, M., et al.: Jpn. J. Exp. Med., 48, 401 (1978), Shindo, H., et al.: Chemoterapy, 27, 64 (1979), Nishida, M., et al.: J. Antibiot., 32, 1319 (1979),

Cefmetazole lactone is an antibiotic, classified as a cephalosporin, which is a type of β-lactam antimicrobial compound. It is derived from the Cephalosporium fungus, known for its progenitor antimicrobial properties. As a second-generation cephalosporin, cefmetazole lactone operates by inhibiting bacterial cell wall synthesis, essentially interfering with the transpeptidation process of peptidoglycan, a critical component of the bacterial cell wall. This disruption leads to cell lysis and eventual bacterial death, mainly affecting Gram-positive and some Gram-negative bacteria. Cefmetazole lactone is predominantly utilized in the treatment of infections caused by susceptible bacterial strains, including respiratory tract infections, urinary tract infections, and skin and soft tissue infections. Its efficacy in targeting specific pathogens makes it a valuable option in clinical settings where resistance to other antibiotics emerges. Researchers continue to evaluate its pharmacokinetics and spectrum of activity to better understand and optimize its clinical applications and potential combination therapies.