Phenol, 4-nitro-2-phenoxy- (CAS 70995-08-3) is an organic compound characterized by its phenolic structure, which includes a nitro group and a phenoxy group. This compound typically exhibits a pale yellow to brownish color and is soluble in organic solvents, while being less soluble in water due to its hydrophobic phenolic structure. The presence of the nitro group introduces significant electron-withdrawing characteristics, which can influence the compound's reactivity and stability. It is often used in various chemical syntheses and may serve as an intermediate in the production of dyes, pharmaceuticals, and agrochemicals. The compound's properties, such as melting point, boiling point, and specific reactivity, can vary based on its purity and the conditions under which it is handled. As with many nitro-substituted phenols, it may exhibit toxicity and should be handled with appropriate safety precautions in a laboratory setting.

Phenol, 4-nitro-2-phenoxy-

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Nimesulide EP Impurity G

Applications 4-​Nitro-​2-​phenoxyphenol is a impurity of Nimesulide (N477500), antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-alpha production. Also used in the preparation of benzoxirenes and the synthesis of trioxonins.
References Pairet, M., et al.: Inflamm. Res., 47, S93 (1998), Fukutake, M., et al.: Carcinogenesis, 19, 1939 (1998), Okajima., E., et al.: Cancer Res., 58, 3028 (1998), Azab, A., et al.: Life Sci., 63, 323 (1998)


4-Nitro-2-phenoxyphenol

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CAS 70995-08-3: Phenol, 4-nitro-2-phenoxy-

Nimesulide EP Impurity G

Ref: 4Z-N-0811

Nimesulide EP Impurity G

Ref: ST-EA-CP-N23007

4-Nitro-2-phenoxyphenol

Ref: TR-N496978

4-Nitro-2-phenoxyphenol

Ref: 86-MM0378.07

4-Nitro-2-phenoxyphenol

Ref: 3D-VCA99508