CAS 71204-89-2: Calcitroic acid

Stability Light Sensitive Applications Calcitroic Acid is a major metabolite of Calcitriol (C144500). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Esvelt, R.P. et al.: Arch. Biochem. Biophys., 206, 403 (1981); Onisko, B.L. et al.: Biochemistry, 19, 4124 (1980); Reddy, G.S. et al.: Biochemistry, 28, 1763 (1989);

Calcitroic acid is a metabolite of vitamin D, which is derived from the enzymatic degradation of calcitriol, the hormonally active form of vitamin D3. This compound is found within biological systems as a result of the breakdown processes occurring in the liver and kidneys, orchestrated by specific enzyme activities that convert calcitriol into calcitroic acid. Its mode of action involves participation in the metabolic pathways that facilitate the regulation of calcium and phosphate homeostasis in the body, albeit as a less active form compared to its precursor, calcitriol. In terms of applications, calcitroic acid is primarily studied within the context of vitamin D metabolism and its role in calcium signaling pathways. Its presence and concentration can be indicative of vitamin D catabolism and are of particular interest in research focused on bone health, mineral metabolism, and related disorders. Understanding the dynamics of calcitroic acid formation and clearance can provide insights into conditions characterized by dysregulated vitamin D metabolism, making it a noteworthy subject in clinical biochemical research.