CAS 72064-79-0: (11β)-21-(Acetyloxy)-11-hydroxy-17-[(1-oxopentyl)oxy]pregna-1,4-diene-3,20-dione

Prednisolone valerate acetate is a prodrug anti-inflammatory and immunosuppressive,converted to the active form of Prednisolone and glucocorticoid receptor.

Prednisolone valeroacetate is a synthetic corticosteroid, which is a chemically modified derivative of prednisolone. It originates from chemical synthesis processes designed to enhance specific therapeutic effects and mitigate side effects. This compound acts primarily by modulating the immune system and exerting anti-inflammatory effects. Its mechanism of action involves the inhibition of phospholipase A2, leading to a reduction in the synthesis of proinflammatory mediators like prostaglandins and leukotrienes. Additionally, it suppresses the migration of immune cells to sites of inflammation, thereby reducing immune responses. The primary use of Prednisolone valeroacetate is in dermatological applications, where it is topically administered to treat inflammatory skin conditions such as eczema and dermatitis. Its efficacy in reducing swelling, redness, and itching makes it a crucial option in dermatological therapeutics. Furthermore, this corticosteroid is formulated to ensure optimal skin penetration and prolonged action at the target site, thereby increasing its therapeutic effectiveness while minimizing systemic absorption and the associated side effects common with oral corticosteroids.