CAS: 723331-20-2

Applications ZJ 43 is a glutamate carboxypeptidase II (GCPII) and N-acetylaspartylglutamate (NAAG) inhibitor that reduces the deleterious effects of excessive extracellular glutamate. References Feng, J. et al.: Brain Res., 1469, 144 (2012); Zuo, D. et al.: J. Biol. Chem., 287, 21773 (2012); Feng, J. et al.: Brain Res., 1395, 62 (2011)

ZJ 43 is an advanced biochemical compound that serves as a precision-targeted reagent, specifically designed for cellular and molecular biology applications. Derived from synthetic organic chemistry techniques, it features a high degree of purity and specificity, allowing it to interact with cellular proteins without significant off-target effects. The compound primarily operates by modulating the activity of protein kinases, crucial enzymes in signaling pathways. ZJ 43 achieves this through a mechanism of competitive inhibition, where it binds to the active site of the kinase, thereby preventing substrate access and subsequent phosphorylation events. This selective inhibition is critical for dissecting signaling pathways in various experimental contexts. In terms of applications, ZJ 43 is employed extensively in research aimed at understanding the intricacies of signal transduction mechanisms and cellular responses to external stimuli. Its specificity makes it an invaluable tool in both basic and applied research, facilitating the development of targeted therapies for diseases where dysregulation of kinase activity is a contributing factor. Scientists leverage its properties to elucidate cellular processes at a molecular level, contributing to the advancement of precision medicine.