CAS 73335-78-1: 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-bromo-3,3-dimethyl-7-oxo-, sodium salt, [2S-(2α,5α,6β)]-

Stability Hygroscopic Applications Brobactam is a potent semi-synthetic β-lactamase inhibitor as well as an impurity of Sulbactam (S699185). References Melchior, N.H. et al.: Proc. Int. Congr. Chemother., 3, 55 (1983);

Brobactam Sodium Salt is a β-lactamase inhibitor.

Brobactam sodium is a β-lactamase inhibitor, which is a chemically synthesized compound with the primary function of inactivating β-lactamase enzymes produced by certain bacteria. These enzymes can degrade β-lactam antibiotics, such as penicillins and cephalosporins, rendering them ineffective. Brobactam sodium functions by forming a covalent bond with the active site of β-lactamase enzymes, thus inhibiting their activity and allowing the concomitantly administered β-lactam antibiotic to exert its bactericidal effect on the susceptible pathogens. The primary application of Brobactam sodium is in combination therapies with β-lactam antibiotics to treat infections caused by β-lactamase-producing bacteria. This includes a range of Gram-positive and Gram-negative bacteria that are otherwise resistant to standard β-lactam antibiotics alone. Its use is critical in both clinical and research settings to study antibiotic resistance mechanisms and to develop effective therapeutic strategies against resistant bacterial infections.