CAS 73466-12-3: (-)-leukotriene A4

Leukotriene A4 methyl ester is a specialized biochemical compound, which is a leukotriene derivative, synthesized from arachidonic acid. Leukotrienes are lipid mediators predominantly produced by leukocytes. This compound serves as a stable, methylated analog of Leukotriene A4, facilitating studies related to leukotriene pathways due to its increased stability compared to its non-esterified counterpart. Leukotriene A4 methyl ester functions by mimicking the biochemical activities of native leukotriene molecules, engaging in pathways that regulate inflammatory responses and immune signaling. Within cellular environments, leukotrienes are potent mediators that influence vascular permeability, bronchoconstriction, and leukocyte recruitment, thus playing critical roles in conditions such as asthma and allergic reactions. This compound is primarily used in research settings to investigate the biochemical and physiological roles of leukotrienes. It aids in the elucidation of leukotriene-related mechanisms and the development of therapeutic strategies targeting inflammatory diseases. Experimental applications involve its use as a tool to dissect the complex cascade of reactions mediated by leukotrienes, thereby contributing to both fundamental and translational research in immunology and pharmacology.

Leukotriene A4 methyl ester can be converted into leukotriene C4 monomethyl ester catalyzed by the major alkaline cytosolic glutathione transferase in rat liver