CAS 73971-82-1: 2,4(1H,3H)-Pyrimidinedione,1-(3-azido-2,3-dideoxy-b-D-threo-pentofuranosyl)-5-methyl-

1-(3-Beta-azido-2,3-dideoxy-beta-D-threopentafuranosyl)thymine is an inhibitor of ion channels. It is a ligand that binds to the beta subunit of voltage-gated potassium channels and blocks the opening of these channels. The binding site for 1-(3-Beta-azido-2,3-dideoxy-beta-D-threopentafuranosyl)thymine has been identified as being located in the selectivity filter region at the extracellular side of the channel. This compound has shown to be a potent inhibitor of ion channels with IC50s in the low nanomolar range.

3’-N-modified nucleoside; Azido-nucleoside