3-Acetylthio-2-methylpropionyl chloride is an organic compound characterized by its functional groups, including an acyl chloride and a thioether. It typically appears as a colorless to pale yellow liquid with a pungent odor, indicative of the presence of the acyl chloride moiety. The compound is known for its reactivity, particularly in nucleophilic substitution reactions, where the acyl chloride can react with various nucleophiles, including amines and alcohols, to form corresponding amides or esters. It is also used in organic synthesis as an intermediate in the preparation of other chemical compounds, particularly in the pharmaceutical and agrochemical industries. Due to the presence of the thioether group, it may exhibit unique properties such as increased lipophilicity and potential biological activity. Safety precautions are essential when handling this compound, as it can be corrosive and may cause irritation to the skin, eyes, and respiratory system. Proper storage in a cool, dry place, away from moisture and incompatible substances, is also recommended to maintain its stability.

3-Acetylthio-2-methylpropionyl chloride

74345-73-6: ethanethioic acid, S-[(2R)-3-chloro-2-methyl-3-oxopropyl] ester, S-[(2R)-3-Chloro-2-methyl-3-oxopropyl] ethanethioate

Captopril Impurity 8

Captopril Related Compound 4

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Applications (2R)-3-Acetylthio-2-methylpropionyl Chloride is a reactant used in the preparation of Captopril (C175750) analogs as inhibitors of angiotensin converting enzyme.
References Rubin, B., et al.: Eur. J Pharmacol., 51, 377 (1978); Hanessian, S., et al.: Bioorg. Med. Chem. Lett., 8, 2123 (1998);


CAS 74345-73-6: 3-Acetylthio-2-methylpropionyl chloride

Captopril Impurity 8

Ref: 4Z-C-1728

Captopril Related Compound 4

Ref: ST-EA-CP-C53010

3-Acetylthio-2-methylpropionyl chloride

Ref: 3D-FA71852

(2R)-3-Acetylthio-2-methylpropionyl Chloride

Ref: TR-A188675