CAS 74764-17-3: N-(pyridin-2-yl)ethane-1,2-diamine

Applications N-2-Pyridinyl-1,2-ethanediamine is a reactant used in the synthesis of dual histamine H1 and H2 receptor antagonists based on cyanoguanidine. Also used in the synthesis of 2-thiohydantoins as somatostatin receptor ligands, References Sadek, B. et al.: Molecules, 18, 14186 (2013); Wang, X. et al.: Lett. Drug Design. DIsc., 9, 655 (2012);

N-2-Pyridinyl-1,2-ethanediamine is an inhibitor of glycogen synthase kinase 3β (GSK3β), which is a protein that regulates the balance between glycogen synthesis and degradation in the liver. Type 2 diabetes is characterized by impaired insulin secretion and reduced insulin sensitivity, leading to hyperglycemia. N-2-Pyridinyl-1,2-ethanediamine has been shown to reduce plasma glucose concentration in type 2 diabetics when administered orally. It also increases glycogen content in hepatocytes through inhibition of GSK3β.