CAS 75056-11-0: Riddelline N-oxide

Riddelliin-N-oxide is a pyrrolizidine alkaloid, which is a naturally occurring compound found predominantly in certain species of plants, such as those belonging to the Senecio genus. Pyrrolizidine alkaloids are primarily derived from the metabolism of plants and serve as a chemical defense against herbivory. Riddelliin-N-oxide operates through its ability to interfere with cellular activities by forming DNA adducts once metabolized into its reactive intermediates. This makes it a compound of interest in the study of genotoxicity and mutagenicity. The primary uses and applications of Riddelliin-N-oxide are centered around toxicological research. It serves as a model compound for understanding the mechanisms of alkaloid-induced toxicity and carcinogenicity in biological systems. Additionally, its presence in certain plants raises concerns for animal and human health, necessitating studies on exposure risk and safety assessments in agriculture and food safety. Scientists investigate its effects in vitro and in vivo to elucidate metabolic pathways and to potentially inform regulatory guidelines in the context of environmental and dietary exposure.

Natural alkaloid