CAS 75433-99-7: 6-methoxyquinoline-2-carboxylic acid

6-Methoxyquinoline-2-carboxylic acid (6MQ) is a cytotoxic agent that binds to DNA and inhibits transcription. It has high affinity for the sequence GACCCT, which is found in many genes encoding ribosomal RNA. 6MQ also acts by binding to the chromophore of nucleic acids and inhibiting their synthesis. This drug can bind to divalent metal ions and inhibit bacterial growth by preventing protein biosynthesis. 6MQ also has fluorescence properties, which may be used to monitor its concentration in cells. The compound's sequence can be determined using NMR spectroscopy, which provides information about the number of hydrogen atoms present on each carbon atom and the number of double bonds in each molecule.