8-Chloroquinazoline is a heterocyclic organic compound characterized by a quinazoline core structure, which consists of a fused benzene and pyrimidine ring. The presence of a chlorine atom at the 8-position of the quinazoline ring significantly influences its chemical properties and reactivity. This compound typically appears as a crystalline solid and is known for its potential biological activity, including applications in medicinal chemistry as a scaffold for drug development. It may exhibit various pharmacological effects, making it of interest in the fields of oncology and infectious disease research. The compound is generally soluble in organic solvents, and its reactivity can be attributed to the electron-withdrawing nature of the chlorine substituent, which can affect nucleophilic attack and other chemical interactions. Safety data should be consulted for handling and storage, as with many halogenated compounds, it may pose health risks if not managed properly. Overall, 8-chloroquinazoline serves as a valuable compound in both synthetic and medicinal chemistry contexts.

8-chloroquinazoline

7557-04-2: Quinazoline, 8-Chloro-, 8-Chloroquinazoline

8-Chloroquinazoline

8-Chloroquinazoline is a glutamic acid substituted quinazoline that has been shown to have potent inhibitory activity against the amyloid precursor protein (APP) in vitro and in vivo. It has also been shown to be an electron microscopic marker for Alzheimer's disease. 8-Chloroquinazoline can be used as a chemotherapeutic agent for Alzheimer's disease, but it is not yet known whether it is effective in humans. The compound is structurally related to curcumin and donepezil, which are vitamin B6 derivatives that are used for the treatment of Alzheimer's disease. 8-Chloroquinazoline inhibits APP cleavage by binding to the active site of β-secretase and γ-secretase enzymes, preventing the formation of β-amyloid peptides.

CAS 7557-04-2: 8-chloroquinazoline

8-Chloroquinazoline

Ref: 10-F692399

8-Chloroquinazoline

Ref: 54-OR1026600

8-Chloroquinazoline

Ref: IN-DA0039SU

8-Chloroquinazoline

Ref: 3D-FC161043