CAS: 757220-04-5

Di-N-desethyl Amiodarone hydrochloride, a metabolite of Amiodarone, functions as a potent inhibitor of the respiratory chain [1].

Impurity Amiodarone Didesethyl Impurity Applications A novel metabolite of Amiodarone in plasma. Amiodarone Didesethyl Impurity References Elvin, A., et al.: J. Pharm. Sci., 69, 47 (1980), Ou, C., et al.: Clin. Chem., 36, 532 (1990), Julian, D., et al.: Lancet, 349, 667 (1997), Ha, H., et al.: Eur. J. Clin. Pharmacol., 55, 807 (2000), Ha, H., et al.: Drug Metab. Dispos., 29, 152 (2001),

Di(N-desethyl) amiodarone hydrochloride is an impurity of Amiodarone Hydrochloride, which is a drug that is used to treat and prevent serious ventricular arrhythmias. Di(N-desethyl) amiodarone hydrochloride can be synthesized from the corresponding parent compound by desmethylation with trifluoroacetic acid. It has been shown to have a low solubility in water and it is soluble in acetones, ethers, and chloroform. This impurity can be used as a HPLC standard for the analysis of Amiodarone Hydrochloride or as an analytical reference material for other liquid chromatography methods.