CAS 76-03-9: Trichloroacetic acid

Trichloroacetic acid is a sodium salt that is used to dissolve proteins in biological samples. It is also used as a disinfectant and antiseptic. Trichloroacetic acid has been shown to be toxic to cells by inhibiting the synthesis of DNA duplexes, leading to cell death. The use of trichloroacetic acid for this purpose has been studied in wild-type strains and in human serum. Trichloroacetic acid is often used together with sodium trifluoroacetate, which increases the solubility of the molecule and helps it penetrate tissue better.

Trichloroacetic acid, commonly used for facial chemical resurfacing, is a metabolite of trichloroethylene, believed to contribute to its hepatocarcinogenic effects in mice.

Protein precipitation reagentTrichloroacetic acid is used as a precipitating agent in biochemistry for precipitation of proteins, DNA and RNA. It is an active ingredient used in cosmetic treatments like chemical peels, tattoo removal and the treatment of warts including genital warts. It is also used to determine protein concentration and as a decalcifier and fixative in microscopy. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications 2,2,2-Trichloro-acetic Acid is an acetic acid analogue used for the precipitation of macromolecules including proteins, DNA and RNA as well as for cosmetic treatments. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Wiley D. et al.: Clin. Infect. Dis., 35m S210 (2002);

Trichloroacetic acid