CAS 76-83-5: Trityl chloride

Chlorotriphenylmethane (TriphenylMethyl chloride) is a biochemical substance.

Trityl chloride is an organic compound that has high chemical stability. It is mainly used as a reagent in organic synthesis and polymer chemistry. Trityl chloride reacts with alkanoic acids to form esters by the reaction of the acid chloride with alcohols. Trityl chloride reacts with trifluoroacetic acid to form carboxylic acid chlorides, which are often used as chiral synthons in asymmetric synthesis. The coordination geometry of the trityl ligand is octahedral and it binds to metal cations through three oxygen atoms and two adjacent nitrogen atoms. The polymer compositions can be chiral due to the presence of chiral trityl groups, which can lead to different physical properties such as solubility or melting point.

Chlorotriphenylmethane is used as laboratory chemical. It acts as a protecting reagent for thiols, alcohols and amines. It is used in organic synthesis for initiating trityl group protection and for preparing S-trityl-L-cysteine (STLC), a inhibitor of Eg5 prevents mitotic progression. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications Trityl Chloride is an alkyl halide commonly used in organic synthesis to introduce the trityl protecting group. Trityl Chloride is used in the preparation of S-trityl-L-cysteine (STLC), a tight-binding inhibitor of Eg5 that prevents mitotic progression. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References DeBonis, S. et al.: J. Med. Chem., 51, 1115 (2008); Chadwick, D.J. et al.: J. Chem. Soc. Perk. Trans. Org. Bio-Org. Chem., 1, 102 (1983);

Trityl chloride

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

M02871 - Trityl chloride

Chlorotriphenylmethane

Trityl chloride is an organic compound that is used as a reagent, intermediate, and building block in the synthesis of other compounds. It has many uses as a fine chemical and research chemical. Trityl chloride can be used to synthesize various polymers, pharmaceuticals, and pesticides. The CAS number for trityl chloride is 76-83-5.