CAS 762-21-0: Diethyl acetylenedicarboxylate

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Diethyl acetylenedicarboxylate is a dicarboxylic acid that is used in wastewater treatment. It reacts with trifluoroacetic acid to form a stable complex. This compound has been shown to inhibit HIV infection by binding to the viral envelope protein gp120 and blocking the interaction with its receptor. Diethyl acetylenedicarboxylate also inhibits the growth of bacteria and fungi, as well as inhibiting the formation of skin lesions in mice infected with S. aureus. This compound also has antimicrobial properties due to its ability to react with metal carbonyls, such as copper or silver, which can be found on certain surfaces, such as copper coins or silverware.

Diethyl acetylenedicarboxylate is used as a protein cross-linker. It is also used in the synthesis of 3,4,5-trisubstituted 2(5H)-furanone derivatives, highly functionalized thiazolidinone derivatives, novel cyclic peroxide glucosides and 4,11-dimesitylbisanthene, soluble bisanthene derivative, via Diels-Alder reaction. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Diethyl but-2-yne-1,4-dioate