CAS 768-33-2: Chlorodimethylphenylsilane

Applications Phenyldimethylchlorosilane can be used as a catalyst in the carboxylation of toluene with carbondioxide. References Zhang, Xibao, et al.: AIChE J., 63(1),  185-191 (2017)

Phenyl-Containing Blocking Agent Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure. Aromatic Silane - Conventional Surface Bonding Aliphatic, fluorinated aliphatic or substituted aromatic hydrocarbon substituents are the hydrophobic entities which enable silanes to induce surface hydrophobicity. The organic substitution of the silane must be non-polar. The hydrophobic effect of the organic substitution can be related to the free energy of transfer of hydrocarbon molecules from an aqueous phase to a homogeneous hydrocarbon phase. A successful hydrophobic coating must eliminate or mitigate hydrogen bonding and shield polar surfaces from interaction with water by creating a non-polar interphase. Although silane and silicone derived coatings are in general the most hydrophobic, they maintain a high degree of permeability to water vapor. This allows coatings to breathe and reduce deterioration at the coating interface associated with entrapped water. Since ions are not transported through non-polar silane and silicone coatings, they offer protection to composite structures ranging from pigmented coatings to rebar reinforced concrete. A selection guide for hydrophobic silanes can be found on pages 22-31 of the Hydrophobicity, Hydrophilicity and Silane Surface Modification brochure. Phenyldimethylchlorosilane; Chlorodimethylphenylsilane; Dimethylphenylchlorosilane Viscosity: 1.4 cStΔHvap: 47.7 kJ/molVapor pressure, 25 °: 1 mmForms cuprateUsed in analytical proceduresSummary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure

Chlorodimethylphenylsilane is used in the synthesis of enantioenriched allenylsilanes through an ortho-ester Claisen rearrangement of chiral and silylpropargylic alcohols. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

S13375 - Phenyldimethylchlorosilane

Dimethylphenylsilylchloride is an analytical reagent that is used for the determination of p-hydroxybenzoic acid in various types of samples. It reacts with p-hydroxybenzoic acid to form a methyl ester, which can be detected by UV spectrophotometry and quantified using a calibration curve. The rotarod test is an animal model that has been used to measure the disease activity of endometriosis and autoimmune diseases. Dimethylphenylsilylchloride also serves as a reactant in the preparation of dimethyl fumarate from sodium carbonate, which can be used as a drug for bowel disease. Dimethylphenylsilylchloride is also able to induce transcription-quantitative polymerase chain reaction (RT-qPCR) in human cells and has been shown to induce eye disorders such as cataracts and glaucoma. This compound has also been shown to have negative effects on

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Chloro(dimethyl)phenylsilane