CAS: 76824-16-3

Famotidine impurity D CRS

Impurity Famotidine EP Impurity D Stability Hygroscopic Applications 3-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]propanamide is an impurity in the synthesis of Famotidine (F102250) histamine H2-receptor antagonist. Antiulcerative. References Takeda, M., et al.: Arzneim.-Forsch., 32, 734 (1982), Miwa, M., et al.: J. Clin. Pharmacol. Ther. Toxicol., 22, 214 (1984), Takabatke, T., et al.: Eur. J. Clin. Pharmacol., 28, 327 (1985),

3-[[[2-[(Diaminomethylene)amino]-4-thiazolyl]methyl]thio]propanamide is a synthetic drug product. It is not found in natural products and it has no pharmacopoeia name. 3-[[[2-[(Diaminomethylene)amino]-4-thiazolyl]methyl]thio]propanamide is an impurity standard for the manufacture of pharmaceuticals. It is also used as a research and development reagent and analytical standard. 3-[[[2-[(Diaminomethylene)amino]-4-thiazolyl]methyl]thio]propanamide has not been evaluated by the FDA as a food additive, but it has been evaluated by the European Union as a flavoring agent.

Famotidine degradation impurity 2

"Famotidine propanamide blocks H2-receptors to reduce stomach acid, treating ulcers and GERD."

Applications Famotidine impurity. References Junnarkar, G., et al.: Pharm. Res., 12, 599 (1995), Singh, S., et al.: J. Pharm. Sci., 91, 253 (2002),

Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure