2'-Deoxy-5-fluoro-5'-O-nitrouridine is a nucleoside analog that features a modified uridine structure. This compound is characterized by the presence of a fluorine atom at the 5-position of the uracil base and a nitro group at the 5'-O position, which contributes to its unique chemical properties. The substitution of the hydroxyl group with a nitro group enhances its stability and may influence its biological activity. As a nucleoside analog, it can potentially interfere with nucleic acid synthesis and function, making it of interest in antiviral and anticancer research. The presence of the deoxy group indicates that it lacks an oxygen atom at the 2' position, distinguishing it from ribonucleosides and affecting its interaction with nucleic acid polymerases. Overall, 2'-deoxy-5-fluoro-5'-O-nitrouridine is a compound of significant interest in medicinal chemistry, particularly for its potential therapeutic applications.

2'-deoxy-5-fluoro-5'-O-nitrouridine

77421-85-3: Uridine, 2'-deoxy-5-fluoro-, 5'-nitrate

[(2R,3S,5R)-5-(5-Fluoro-2,4-Dioxopyrimidin-1-Yl)-3-Hydroxyoxolan-2-Yl]Methyl Nitrate is a pyrimidine derivative that inhibits the synthesis of thymidylate. It has been shown to have cytotoxic effects on the L1210 mouse leukemia cell line and on cultures of lactobacillus. [(2R,3S,5R)-5-(5-Fluoro-2,4-Dioxopyrimidin-1-Yl)-3-Hydroxyoxolan-2-Yl]Methyl Nitrate also inhibits the activity of thymidylate synthetase in ascites cells.

CAS 77421-85-3: 2'-deoxy-5-fluoro-5'-O-nitrouridine

[(2R,3S,5R)-5-(5-Fluoro-2,4-Dioxopyrimidin-1-Yl)-3-Hydroxyoxolan-2-Yl]Methyl Nitrate

Ref: 3D-FF101085