7-Chloro-4-{4-[(4-chlorophenyl)sulfonyl]piperazin-1-yl}quinoline, with the CAS number 774549-97-2, is a synthetic organic compound characterized by its complex structure, which includes a quinoline core substituted with a chloro group and a piperazine moiety linked through a sulfonyl group. This compound exhibits properties typical of quinoline derivatives, including potential biological activity, particularly in the realm of medicinal chemistry. The presence of the chloro substituents and the sulfonyl group may enhance its pharmacological profile, possibly contributing to its efficacy in targeting specific biological pathways. The piperazine ring is often associated with improved solubility and bioavailability in drug design. As a result, compounds like this one are of interest in the development of therapeutic agents, particularly in the treatment of various diseases, including infections and cancers. Its specific interactions and mechanisms of action would require further investigation through experimental studies to fully elucidate its potential applications in pharmacotherapy.

7-chloro-4-{4-[(4-chlorophenyl)sulfonyl]piperazin-1-yl}quinoline

774549-97-2: 7-Chloro-4-{4-[(4-Chlorophenyl)Sulfonyl]Piperazino}Quinoline, Quinoline, 7-chloro-4-[4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl]-

KM11060 is a peptide that has been shown to activate the ion channel TRPV1. It also inhibits the interaction of the receptor with its ligand. KM11060 is a potent inhibitor of TRPV1, and has been shown to inhibit the binding of ATP to TRPV1. KM11060 also inhibits the binding of ATP to TRPV2 and TRPA1 channels, but not TRPM8 channels.
TRPV1 channels are activated by several stimuli, including heat (>42°C), acidic pH (4.5), and capsaicin (the active ingredient in chili peppers). The activation of these channels leads to an influx of calcium ions into the cell, which can trigger pain sensations and inflammation.

KM11060

KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma

CAS 774549-97-2: 7-chloro-4-{4-[(4-chlorophenyl)sulfonyl]piperazin-1-yl}quinoline

KM11060

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KM11060

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KM11060

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