CAS 78214-33-2: Ginsenoside Rh2

Natural glycoside

Applications 20(S)-Ginsenoside Rh2 is a bioactive metabolite of the ginsenoside component of Panax ginseng that has been shown to exhibit antibacterial effects in vitro. References Zhang, J. et al.: Eur. J. Pharm., 740, 277 (2014);

Ginsenoside Rh2

Ginsenoside Rh2 analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Ginsenoside Rh2 (20(S)-Ginsenoside Rh2), an extract of red Panax ginseng, is a potent anti-inflammatory and anticancer drug.

Ginsenoside Rh2 is a bioactive compound, which is a triterpenoid saponin derived from the root of the Panax ginseng plant. It operates through multiple biochemical pathways, including the modulation of cell signaling cascades such as the inhibition of cell proliferation and the induction of apoptosis in cancer cells. These actions are primarily mediated through mitochondrial pathways and involve the regulation of pro-apoptotic and anti-apoptotic proteins. Ginsenoside Rh2 is extensively utilized in scientific research due to its potential therapeutic applications. It is studied for its anticancer properties, particularly in the context of inhibiting tumor growth and enhancing the efficacy of conventional chemotherapy agents. Additionally, its immunomodulatory effects are of interest in the study of autoimmune diseases. Researchers are also examining its neuroprotective properties which may contribute to advances in the treatment of neurodegenerative diseases. Overall, Ginsenoside Rh2 provides valuable insights into the development of novel therapeutic strategies in various fields of biomedical research.

20(s)-Ginsenoside Rh2 is a bioactive compound classified as a saponin, which is derived from the root of the Panax ginseng plant. This compound exhibits a wide range of pharmacological activities attributed to its ability to modulate cellular pathways. It exerts its mode of action primarily through the regulation of apoptosis, modulation of immune responses, and inhibition of tumor growth. Mechanistically, it interacts with cellular receptors and signaling molecules, influencing pathways such as NF-κB and MAPK, which are crucial in cell proliferation and apoptosis. The applications of 20(s)-Ginsenoside Rh2 are diverse, particularly in the fields of oncology and neuropharmacology. In cancer research, it has been studied for its potential to induce apoptosis in cancerous cells and reduce tumor size. Additionally, its neuroprotective properties make it a candidate for research in neurodegenerative diseases such as Alzheimer's. Beyond its therapeutic potential, it is of interest for geriatric research due to its purported anti-aging effects. Scientists continue to explore its efficacy and mechanisms, making it a promising compound in the development of new therapeutic agents.

Ginsenoside Rh2 is one of the most active components of red ginseng, controlling cancer and other metabolic diseases including osteoclast differentiation; ginsenoside Rh2 can suppress RANKL-induced osteoclast differentiation in vitro and in vivo through the regulation of c-Fos and NFATc1 expressions, not excluding the involvement of NF-κB and ERK, it is also suggested to be developed as a therapeutic drug for prevention and treatment of osteoporosis.