CAS 78858-44-3: (2R)-3-(hexadecyloxy)-2-methoxypropyl 2-(trimethylammonio)ethyl phosphate

2-O-methyl PAF C-16 is a synthetic analog of platelet-activating factor (PAF) featuring a methyl group attached via an ether linkage at the sn-2 position. While the specific biological activities of 2-O-methyl PAF C-16 remain undercharacterized, studies with its C-18 counterpart have demonstrated its ability to modulate various biological processes. These processes include reducing plasma membrane fluidity and hindering the invasiveness of tumor cells in embryonic chick hearts. Furthermore, in rat astrocytes, the C-18 analog prompts the release of significant amounts of nitric oxide (NO) through a mechanism that involves the activation of nitric oxide synthase (NOS).

1-O-Hexadecyl-2-O-methyl-sn-glycero-3-phosphocholine is a useful scaffold, versatile building block, and useful intermediate that can be used in the synthesis of complex compounds. It is a high quality reagent and research chemical that can be used as a reaction component for speciality chemicals. 1-O-Hexadecyl-2-O-methyl-sn-glycero-3-phosphocholine has CAS number 788584443.

1-O-Hexadecyl-2-O-methyl-sn-glycero-3-phosphocholine (HPC) is a phospholipid that is synthesized from the essential fatty acid linoleic acid. It has been shown to have an inhibitory effect on leukemia cells, which may be due to its ability to induce apoptosis by inducing the death of tumor cells and inhibiting protein synthesis. HPC also interacts synergistically with other agents such as phorbol esters, which can lead to increased cell death. This drug has been shown to have immunomodulatory effects in fibrosarcoma cells, where it inhibits tumor growth and induces apoptotic cell death. HPC binds to specific antigens and modulates immune responses through the inhibition of diacylglycerol production.