CAS: 79056-01-2

5(S),12(S)-Dihete is a potent inhibitor with potential anticancer properties. It has been extensively studied for its ability to induce apoptosis in cancer cells by inhibiting kinases that are essential for tumor cell growth and survival. This inhibitor has shown promising results in Chinese hamster ovary cells, human leukemia cells, and other cancer cell lines. Additionally, 5(S),12(S)-Dihete has been found in urine samples of patients undergoing chemotherapy, indicating its potential as a medicinal agent in cancer treatment. Its mechanism of action involves disrupting the cell cycle and interfering with protein synthesis, leading to the inhibition of cancer cell growth and proliferation. Overall, 5(S),12(S)-Dihete shows great promise as a potential anticancer agent and warrants further investigation.

5(S),12(S)-DiHETE is a bioactive lipid from arachidonic acid, made in PMNLs and platelets via lipoxygenases, and is a leukotriene B4 epimer.