Fructose 2,6-diphosphate (F2,6BP) is a crucial regulatory metabolite in carbohydrate metabolism, particularly in glycolysis and gluconeogenesis. It is a bisphosphate derivative of fructose and plays a significant role in the regulation of key enzymes such as phosphofructokinase-1 (PFK-1) and fructose-1,6-bisphosphatase. F2,6BP is synthesized from fructose-6-phosphate by the enzyme phosphofructokinase-2 (PFK-2) and can be hydrolyzed back to fructose-6-phosphate by fructose-2,6-bisphosphatase. This compound is characterized by its ability to enhance the affinity of PFK-1 for its substrate, thus promoting glycolysis when energy is needed. Conversely, it inhibits fructose-1,6-bisphosphatase, reducing gluconeogenesis. F2,6BP levels are tightly regulated by hormonal signals, particularly insulin and glucagon, reflecting the metabolic state of the cell. Its role as a signaling molecule highlights its importance in maintaining glucose homeostasis and energy balance in various tissues, especially in the liver and muscle.

Fructose 2,6-diphosphate

79082-92-1: D-Fructose 2,6-diphosphate, Fructose 2,6-bisphosphate, Fructose 2,6-diphosphate, β-D-Fructose 2,6-diphosphate, β-D-Fructofuranose, 2,6-bis(dihydrogen phosphate)

CAS 79082-92-1: Fructose 2,6-diphosphate

Fructose 2,6-Diphosphate

Ref: 4Z-F-161019