CAS 796967-16-3: Linifanib
Formula:C21H18FN5O
InChI:InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
InChI key:InChIKey=MPVGZUGXCQEXTM-UHFFFAOYSA-N
SMILES:NC=1C2=C(C=CC=C2NN1)C3=CC=C(NC(NC4=C(F)C=CC(C)=C4)=O)C=C3
Synonyms:- Abt 869
- Al 39324
- Linifanib
- Linigfanib
- N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N′-(2-fluoro-5-methylphenyl)urea
- Rg 3635
- Urea, N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)-
- 1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea
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Found 9 products.
Linifanib
CAS:Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) andFormula:C21H18FN5OPurity:98% - 98.24%Color and Shape:SolidMolecular weight:375.4Ref: TM-T2514
5mg50.00€10mg85.00€25mg126.00€50mg188.00€100mg274.00€200mg505.00€500mg815.00€1mL*10mM (DMSO)52.00€Linifanib
CAS:Linifanib is a cyclic peptide that inhibits the mcl-1 protein, which is involved in the regulation of apoptosis. Linifanib has been shown to inhibit the expression of genes encoding for proteins involved in the signal pathways and angiogenic process, such as VEGF-A and MMP2 respectively. This drug has also been shown to inhibit cancer cell proliferation in vitro and in vivo models. The mechanism of action of linifanib is not yet fully known but it is thought to be due to its ability to induce autophagy or apoptosis. It can be used for the treatment of renal cell cancer and eye disorders such as age-related macular degeneration (AMD).Formula:C21H18FN5OPurity:Min. 95%Molecular weight:375.4 g/molRef: 3D-FL24895
Discontinued productN-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea
CAS:Formula:C21H18FN5OPurity:%Color and Shape:SolidMolecular weight:375.3989Linifanib
CAS:Formula:C21H18FN5OPurity:>95.0%(HPLC)(qNMR)Color and Shape:White to Light yellow powder to crystalMolecular weight:375.411-[4-(3-Amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea
CAS:1-[4-(3-Amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)ureaMolecular weight:375.40g/mol1-(4-(3-Amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:375.4070129394531Linifanib
CAS:Applications Linifanib (ABT 869) is an oral tyrosine kinase inhibitor with antineoplasic activity. As a dual inhibitor, Linifanib, is being tested on several different cancers. References Haddley, K., et al.: Drugs of the Future, 35, 106 (2010), Cheng, A., et al.: J. Med. Chem., 53, 4502 (2010),Formula:C21H18FN5OColor and Shape:NeatMolecular weight:375.40
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