CAS 79722-21-7: tert-butyl N-(benzyloxy)carbamate

Tert-butyl N-(benzyloxy)carbamate is a drug that inhibits bacterial growth by binding to siderophores and blocking the activity of iron-scavenging proteins. It has been shown to inhibit the growth of both Gram-positive and Gram-negative bacteria, including some strains resistant to other antibiotics. It also shows synergistic effects when combined with erythromycin or penicillin. Tert-butyl N-(benzyloxy)carbamate is synthesised in acidic pH conditions using a solid phase synthesis technique. The drug was found to be active against Gram-positive and Gram-negative bacteria as well as anaerobic bacteria, but not against fungi.

Applications tert-Butyl N-(Benzyloxy)carbamate has been used in the synthesis of Deferoxamine Mesylate (D228980), an iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients References Bergeron RJ, et al. 1992. J Med Chem. Dec 11;35(25):4739-44Inati A, et al. 2010. Am J Hematol. Oct;85(10):782-6 Selim M, et al. 2010. Transl Stroke Res. Mar;1(1):35-9

tert-Butyl (benzyloxy)carbamate