Hirudin is a naturally occurring peptide that serves as a potent anticoagulant, primarily derived from the saliva of leeches, particularly the species Hirudo medicinalis. It functions by specifically inhibiting thrombin, an enzyme crucial for blood coagulation, thereby preventing the conversion of fibrinogen to fibrin and ultimately reducing blood clot formation. Hirudin is composed of a sequence of amino acids, typically containing around 65 residues, and exhibits a high degree of specificity and affinity for thrombin. Its structure includes several disulfide bonds that contribute to its stability and biological activity. Due to its anticoagulant properties, hirudin has been studied for therapeutic applications in conditions requiring anticoagulation, such as deep vein thrombosis and pulmonary embolism. Additionally, it has been utilized in research settings to better understand coagulation processes and the mechanisms of thrombin inhibition. As a biopharmaceutical, hirudin is subject to rigorous quality control and characterization to ensure its efficacy and safety in clinical use.

Hirudin

8001-27-2: Exhirud, Exhirudine, Hirudex, Hirudina, Sangsue, Hirudin, (63-tyrosine)hirudin (hv1),leech,rec. F. yeast,  [Tyr63]Hirudin (HV1), leech recombinant, from yeast,  Hirudin, Hirudo medicinalis, Recombinant, Saccharomyces Cere,  Hirudin recombinant from yeast

Hirudin is a potent anticoagulant protein, which is a naturally occurring compound sourced from the salivary glands of medicinal leeches, specifically *Hirudo medicinalis*. It functions by directly inhibiting thrombin, a key enzyme in the blood coagulation process, thereby preventing fibrin formation and subsequent clot development. Hirudin achieves its effects by binding to both the active site and the exosite of thrombin, effectively neutralizing its coagulative activity.

This compound has been widely utilized in various medical and research applications. Clinically, it is employed in settings where anticoagulation is critical, such as in preventing thrombosis during surgeries or in patients with heparin-induced thrombocytopenia. Additionally, Hirudin is a valuable tool in biochemical research, providing insights into thrombin-mediated pathways. Its ability to offer precise inhibition of thrombin makes it an indispensable resource for detailed study of coagulation processes and the development of new anticoagulant therapies.

CAS 8001-27-2: Hirudin

Hirudin from leeches

Ref: 3D-XH173313

Recombinant Hirudin

Ref: 54-BITP1576