CAS 81-49-2: 1-Amino-2,4-dibromo-9,10-anthracenedione

1-Amino-2,4-dibromoanthraquinone is a reactive chemical that has been shown to be carcinogenic in experimental animals. It has been found to induce ovarian tumors in rats and mice. The carcinogenic potential of 1-amino-2,4-dibromoanthraquinone is thought to be due to its ability to form DNA adducts with nucleic acids, resulting in genotoxic effects. These chemical analyses have also shown that 1-amino-2,4-dibromoanthraquinone is an atypical compound, which may contribute to the carcinogenic effects seen in animal studies.

Applications 1-Amino-2,4-dibromo-anthraquinone is a useful compound to study the uPAR·uPA protein-protein interaction (PPI) involved in signaling and proteolytic events that lead to tumor invasion and metastasis. It is also used to evaluate potential renal toxicants based on a relationship between chemical-induced kidney weight gain and kidney histopathology in rats. 1-Amino-2,4-dibromo-anthraquinone is a reagent utilized in copper-catalyzed Ullmann condensation to synthesize anthraquinone derivatives as novel dyes. References Malik, E. M., et al.: Dyes Pigm. 131, 33 (2016); Craig, E. A., et al.: J. Appl. Toxicol. 35, 729 (2015); Mani, T., et al.: Bioorg. Med. Chem 21, 2145 (2013)