CAS: 81103-14-2

Lactones nesoi

6,11-Di-O-methyl erythromycin is a semi-synthetic derivative of erythromycin, which is a macrolide antibiotic originally sourced from the bacterium *Saccharopolyspora erythraea*. This compound is produced through chemical modification of the natural antibiotic to improve its pharmacokinetic properties, such as stability and absorption. The mode of action of 6,11-Di-O-methyl erythromycin is similar to other macrolides; it inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of susceptible bacteria. This binding action prevents the translocation step in protein elongation, effectively halting bacterial growth and proliferation, which makes it bacteriostatic. Due to its potent activity against Gram-positive bacteria and atypical pathogens, 6,11-Di-O-methyl erythromycin is primarily used in research settings to study its enhanced antibacterial properties compared to erythromycin. It can also serve as a lead compound for the development of new antibiotics with improved pharmacological profiles. The chemical modifications provide a valuable tool for scientists investigating the structure-activity relationships and resistance mechanisms in antibiotic research.

Clarithromycin impurity E

Impurity Clarithromycin EP Impurity E Applications 6,11-Di-O-methyl Erythromycin (Clarithromycin EP Impurity E) is a Di-O-alkyl Erythromycin (E649950) is an impurity of Clarithromycin (C559750). Clarithromycin impurity E per British Pharmacopoeia. References Morimoto, S. et al.: J. Antibiot., 43, 286 (1990); Kohno, Y. et al.: J. Antimicrob. Chemother., 26, 503 (1990);