4-(tert-Butyl)-2-chloropyridine is an organic compound characterized by its pyridine ring, which is a six-membered aromatic heterocycle containing one nitrogen atom. The presence of a tert-butyl group at the 4-position and a chlorine atom at the 2-position contributes to its unique chemical properties. This compound typically appears as a colorless to pale yellow liquid or solid, depending on the temperature and purity. It is known for its moderate polarity due to the electronegative chlorine atom, which can influence its solubility in various organic solvents. The tert-butyl group enhances its hydrophobic character, making it less soluble in water. 4-(tert-Butyl)-2-chloropyridine is often utilized in organic synthesis, particularly in the development of pharmaceuticals and agrochemicals, due to its ability to participate in nucleophilic substitution reactions. Additionally, it may exhibit biological activity, making it of interest in medicinal chemistry. Proper handling and storage are essential, as with many chlorinated compounds, to minimize exposure and environmental impact.

4-(tert-butyl)-2-chloropyridine

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4-(tert-Butyl)-2-chloropyridine is a ligand that has been used in the synthesis of a number of boronic acids and quinoline derivatives. It is also useful in cross-coupling reactions, which are nucleophilic substitution reactions involving two partners, such as an organometallic reagent and an organic halide or pseudohalide. The linker can be any group that connects the two partners together for these reactions. 4-(tert-Butyl)-2-chloropyridine is stable under acidic conditions, making it an excellent choice for coupling with amines to produce amides.

CAS 81167-60-4: 4-(tert-butyl)-2-chloropyridine

4-(tert-Butyl)-2-chloropyridine

Ref: 3D-GDA16760

4-tert-Butyl-2-chloro-pyridine

Ref: 10-F304262

4-tert-Butyl-2-chloropyridine

Ref: 54-OR346413

4-(tert-Butyl)-2-chloropyridine

Ref: 3B-B5466

4-(tert-Butyl)-2-chloropyridine

Ref: IN-DA008L0D