CAS 81444-57-7: 13-cis-5,6-Epoxy-5,6-dihydroretinoic acid
Formula:C20H28O3
InChI:InChI=1/C20H28O3/c1-15(8-6-9-16(2)14-17(21)22)10-13-20-18(3,4)11-7-12-19(20,5)23-20/h6,8-10,13-14H,7,11-12H2,1-5H3,(H,21,22)/b9-6+,13-10+,15-8+,16-14-
InChI key:InChIKey=KEEHJLBAOLGBJZ-NJZIYGCENA-N
SMILES:C(=C/C(=C/C=C/C(=C\C(O)=O)/C)/C)\C12C(C)(O1)CCCC2(C)C
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Found 5 products.
5,6-Epoxy-13-cis Retinoic Acid
CAS:Controlled ProductApplications A metabolite of 13-cis-Retinoic Acid (R250000). References Samokyszyn, V., et al.: J. Biol. Chem., 262, 14119 (1987), Oldfield, N., et al.: Drug Metabol. Dispos., 18, 1105 (1990), Samokyszyn, V., et al.: Chem. Res. Toxicol., 10, 795 (1997),Formula:C20H28O3Color and Shape:NeatMolecular weight:316.43Isotretinoin EP Impurity G (5,6-Epoxy-13-cis-Retinoic Acid)
CAS:Formula:C20H28O3Color and Shape:Yellow SolidMolecular weight:316.445,6-epoxy-13-cis Retinoic Acid
CAS:5,6-epoxy-13-cis Retinoic Acid is a metabolite of 13-cis retinoic acid.Formula:C20H28O3Color and Shape:SolidMolecular weight:316.4415,6-Epoxy-13-cis retinoic acid
CAS:5,6-Epoxy-13-cis retinoic acid (5,6-ER) is the most active metabolite of all-trans-retinoic acid. 5,6-ER binds to the nuclear receptor and acts as a transcription factor. It has been shown to inhibit the growth of several cancer cell lines in vitro, including T47D cells. 5,6-ER also has antacid properties and can be used for the treatment of inflammatory bowel disease. 5,6-ER is found in low concentrations in plasma and tissues and accumulates in high concentrations in rat liver microsomes. The major metabolic pathway includes hydrolysis by trifluoroacetic acid which produces 5,6 epoxyretinoyl coenzyme A (5,6 epoxyretinoyl CoA). This compound is then converted to 5,6 epoxyretinol by an unknown mechanism.Formula:C20H28O3Purity:Min. 95%Molecular weight:316.43 g/mol
