CAS 816-66-0: 4-Methyl-2-oxovaleric acid

Stability Hygroscopic Applications Calcium 2-keto-4-methylvalerate ketoacid that can be used as a phosphate binder alternative for patients on peritoneal dialysis, and can be used as a supplement for very low protein diets to maintain nutritional status of patients of chronic kidney disease until arteriovenous fistula made or training for peritoneal dialysis given. References Macia, M., et al.: Clin. Nephrol., 48, 181 (1997); Duenhas, M., et al.: Clin. Nephrol., 79, 387 (2013);

4-Methyl-2-oxopentanoic acid

Ii is an intermediate in the metabolism of leucine and also used as flavoring agents. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

α-Ketoisocaproicacid is an intermediate in the biosynthesis of leucine from α-ketoglutarate. This compound is formed by the decarboxylation of α-ketoglutarate and has been shown to inhibit voltage-dependent calcium channels. It also has a role in regulating intracellular Ca2+ levels, which may be due to its ability to cause cell death in wild type cells. α-Ketoisocaproicacid is an intermediate in the biosynthesis of leucine from α-ketoglutarate. This compound is formed by the decarboxylation of α-ketoglutarate and has been shown to inhibit voltage-dependent calcium channels. It also has a role in regulating intracellular Ca2+ levels, which may be due to its ability to cause cell death in wild type cells. The reaction mechanism involves oxidation of α-ketoisocaproic acid by NADH and reduction

4-Methyl-2-Oxovaleric Acid

4-Methyl-2-oxopentanoic acid, an abnormal metabolite and neurotoxin, results from improper branched-chain amino acid metabolism.